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Creamy Spicy Chicken Spaghetti Casserole
Caroline

Creamy Spicy Chicken Spaghetti Casserole

This Creamy Spicy Chicken Spaghetti Casserole combines tender chicken, spaghetti, and a creamy, cheesy sauce with a touch of heat from green chiles and cayenne pepper. It’s the perfect comfort food for weeknights or meal prep.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 6 servings
Course: Dinner, Main Course
Cuisine: American, Comfort Food
Calories: 480
Ingredients Equipment Method Notes

Ingredients
  

  • 12 oz spaghetti noodles
  • 2 cups cooked shredded chicken
  • 1 can (10.5 oz) cream of chicken soup
  • 1 can (10 oz) diced tomatoes with green chiles
  • 0.5 cup sour cream
  • 1 cup shredded cheddar cheese
  • 0.5 cup shredded mozzarella cheese
  • 0.5 tsp garlic powder
  • 0.5 tsp onion powder
  • 0.5 tsp smoked paprika
  • 0.25 tsp cayenne pepper (optional)
  • salt and black pepper to taste
  • chopped parsley or sliced green onions for garnish

Equipment

  • large pot for boiling pasta
  • mixing bowl
  • 9x13-inch baking dish
  • spatula or mixing spoon
  • Cheese grater

Method
 

  1. Preheat the oven to 350°F (175°C) and lightly grease your baking dish.
  2. Cook the spaghetti according to package directions until al dente, then drain.
  3. In a large bowl, mix shredded chicken, cream of chicken soup, diced tomatoes, sour cream, seasonings, and half of each cheese.
  4. Stir in cooked spaghetti until evenly coated with the creamy mixture.
  5. Pour the mixture into the prepared baking dish, spreading it out evenly.
  6. Sprinkle remaining cheese on top and bake uncovered for 25–30 minutes, until bubbly and golden.
  7. Let it rest for 5 minutes, then top with parsley or green onions before serving.

Notes

  • For best results, use freshly cooked chicken rather than canned.
  • This casserole reheats beautifully—great for lunches or meal prep.
  • You can assemble it ahead of time and refrigerate or freeze before baking.