Cheesy Buffalo Ranch Chicken Lasagna

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If you love rich, cheesy comfort food with a bold kick of flavor, this Cheesy Buffalo Ranch Chicken Lasagna is about to become your new favorite dinner. Combining tender shredded chicken, creamy ranch seasoning, spicy buffalo sauce, and layers of gooey melted cheese, this recipe takes traditional lasagna in an exciting new direction.

Perfect for family dinners, game day gatherings, potlucks, or meal prep, this lasagna delivers restaurant-quality flavor with simple, easy-to-find ingredients. Instead of classic marinara and beef, this version uses a creamy buffalo ranch sauce that coats every layer for maximum flavor. The result is a hearty, satisfying casserole that feels indulgent yet approachable.

Whether you are feeding a crowd or preparing leftovers for the week, this buffalo chicken lasagna is a guaranteed crowd-pleaser that brings comfort food to the next level.

Why You’ll Love This Recipe

• Bold flavor combination: Buffalo sauce and ranch seasoning create a perfectly balanced spicy-creamy profile
• Ultra cheesy: Layers of cheddar, mozzarella, and cream cheese make every bite rich and satisfying
• Great for leftovers: Tastes even better the next day as the flavors meld
• Easy to assemble: Simple layering with no complicated steps
• Versatile: Can be customized to suit spice levels and dietary preferences

Ingredients Breakdown

Understanding each ingredient helps ensure perfect results every time:

• Lasagna noodles: Serve as the structure of the dish, holding together layers of creamy sauce and chicken. Traditional noodles work best, but oven-ready noodles can also be used.
• Rotisserie chicken: Saves time and adds rich, savory flavor. Pre-cooked chicken ensures the lasagna stays moist without drying out.
• Ranch seasoning packet: Adds tangy, herby notes that balance the heat from the buffalo sauce.
• Cream cheese: Forms the base of the creamy sauce, giving the lasagna its signature richness and smooth texture.
• Buffalo sauce: Provides heat, tang, and depth. Adjust the amount based on your spice tolerance.
• Milk: Loosens the sauce slightly so it spreads easily between layers and bakes evenly.
• Cheddar cheese: Adds sharpness and bold flavor that complements the buffalo sauce.
• Mozzarella cheese: Melts beautifully, creating gooey, stretchy layers that make this dish irresistible.

Tips and Tricks

• Soften cream cheese fully: This ensures a smooth sauce without lumps.
• Cook noodles just until al dente: Overcooked noodles can become mushy after baking.
• Shred chicken finely: Smaller pieces distribute flavor more evenly throughout the lasagna.
• Cover while baking: Prevents excessive browning before the inside is fully heated.
• Rest before slicing: Allowing the lasagna to sit helps layers set and makes serving cleaner.

Variations and Customizations

1. Mild version: Use less buffalo sauce or choose a mild buffalo-style sauce.
2. Extra spicy: Add cayenne pepper, hot sauce, or crushed red pepper flakes.
3. Protein swap: Use shredded turkey or grilled chicken breast instead of rotisserie chicken.
4. Cheese changes: Substitute Monterey Jack or Pepper Jack for added heat.
5. Low-carb option: Replace lasagna noodles with thinly sliced zucchini or lasagna-style zucchini sheets.

Pairing Suggestions

• Serve with a crisp green salad and ranch or blue cheese dressing for balance.
• Pair with garlic bread or breadsticks to soak up the creamy sauce.
• Add steamed vegetables like broccoli or green beans for a complete meal.

Storage Instructions

• Refrigerator: Store leftovers in an airtight container for up to 4 days.
• Freezer: Freeze individual portions tightly wrapped for up to 2 months.
• Reheating: Warm in the oven at 350°F or microwave in short intervals until heated through.

Popular Questions

Can I make this lasagna ahead of time?
Yes. Assemble the lasagna, cover tightly, and refrigerate for up to 24 hours before baking.

Is this dish very spicy?
The heat level depends on the buffalo sauce used. Choose mild, medium, or hot based on preference.

Can I use oven-ready noodles?
Yes, but add a few extra tablespoons of milk to ensure proper moisture during baking.

Caroline

Cheesy Buffalo Ranch Chicken Lasagna

A bold and creamy twist on classic lasagna, this Cheesy Buffalo Ranch Chicken Lasagna layers tender rotisserie chicken with ranch-seasoned cream cheese, buffalo sauce, and plenty of melted cheddar and mozzarella for an irresistible comfort meal.

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Prep Time 25 minutes mins

Cook Time 55 minutes mins

Total Time 1 hour hr 20 minutes mins

Servings: 8 servings

Course: Dinner

Cuisine: American

Calories: 520

Ingredients Equipment Method Notes

Ingredients

  

• 12 oz lasagna noodles
• 3 1/2 cups rotisserie chicken, shredded
• 1 packet ranch seasoning
• 24 oz cream cheese, softened
• 1 cup buffalo sauce
• 1/2 cup milk
• 2 cups shredded cheddar cheese
• 2 cups shredded mozzarella cheese

Equipment

• Large pot for boiling noodles
• mixing bowl
• whisk or electric mixer
• 9×13-inch baking dish
• aluminum foil
• spoon or spatula

Method

 

1. Preheat oven to 375°F and lightly grease a 9×13-inch baking dish. Cook lasagna noodles according to package instructions, drain, and set aside.
2. In a large bowl, mix softened cream cheese, ranch seasoning, buffalo sauce, milk, cheddar cheese, and mozzarella until smooth and well combined.
3. Spread a thin layer of the cheese mixture in the bottom of the baking dish. Add a layer of noodles, followed by more cheese mixture and a layer of shredded chicken.
4. Repeat layers until all ingredients are used, finishing with a generous layer of cheese on top.
5. Cover with aluminum foil and bake for 45 minutes.
6. Remove foil and bake an additional 10 minutes until bubbly and lightly golden.
7. Let lasagna rest for 8–10 minutes before slicing and serving.

Notes

Allow the lasagna to rest before slicing for cleaner layers. Drizzle with ranch dressing just before serving for extra creaminess, and garnish with green onions or blue cheese crumbles for added flavor.

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